Many diseases can be described in terms of loss or alterations in identity of specific cell-types and tissues. These include genetic mutations affecting the genome sequence, epigenetic modifications affecting gene expression or inappropriate environmental cues. Such alterations underlie disease states like cancer and metabolic diseases for example diabetes, as well as degenerative pathologies and aging-related conditions. The Who am I? project aim at re-examining pathologies in terms of identity loss with the underlying goal to reveal novel therapeutic strategies based on re-establishing identity.